VTE / ULTRASOUND REFERENCES
EMERGENCY DOCTOR-PERFORMED ULTRASOUND
FIBRINOLYTICS IN VTE
Clinical judgement vs clinical decision aids in PE work-up
The articles supporting the discussion on the role of clinical decision instruments to work up PE
DOCTORS IGNORE CDIS AND SCAN LOW RISK PATIENTS ANYWAY: Sud, R., Langfield, J. and Chu, G. (2013), Heightened clinical suspicion of pulmonary embolism and disregard of the d-dimer assay: a contemporary trend in an era of increased access to computed tomography pulmonary angiogram?. Intern Med J, 43: 1231–1236. doi:10.1111/imj.12225
"DO YOU THINK THIS IS REALLY A PE?" JUST AS GOOD AS WELLS?: Klok FA, Karami Djurabi R, Nijkeuter M, Huisman MV. Alternative diagnosis other than pulmonary embolism as a subjective variable in Wells clinical decision rule: not so bad after all. J Thromb Haemost 2007; 5: 1079–80.
MACHINES GO ON SCANNING SPREE: Wiener RS, Schwartz LM, Woloshin S. Time Trends in Pulmonary Embolism in the United States - Evidence of Overdiagnosis. Arch Intern Med. 2011;171(9):831–837. doi:10.1001/archinternmed.2011.178
SUBJECTIVE JUDGEMENT BETTER THAN DECISION INSTRUMENTS: Wiener RS, Schwartz LM, Woloshin S. Time Trends in Pulmonary Embolism in the United States - Evidence of Overdiagnosis. Arch Intern Med. 2011;171(9):831–837. doi:10.1001/archinternmed.2011.178
THE ORIGINAL WELLS: Wells PS, Ginsberg JS, Anderson DR, et al. Use of a clinical model for safe management of patients with suspected pulmonary embolism. Ann Intern Med. 1998;129:997-1005.
THE ORIGINAL PERC: Kline JA, Mitchell AM, Kabrhel C, Richman PB, Courtney DM. Clinical criteria to prevent unnecessary diagnostic testing in emergency department patients with suspected pulmonary embolism. J Thromb Haemost 2004; 2: 1247–55.
GESTALT VS CDIS FOR ESTIMATING RISK OF PE: Penaloza, Andrea & Verschuren, Franck & Meyer, Guy & Quentin-Georget, Sybille & Soulie, Caroline & Thys, Frédéric & Roy, Pierre-Marie. (2013). Comparison of the Unstructured Clinician Gestalt, the Wells Score, and the Revised Geneva Score to Estimate Pretest Probability for Suspected Pulmonary Embolism. Annals of emergency medicine. 62. 10.1016/j.annemergmed.2012.11.002.
ON WATCHFUL WAITING: Keijzers, G., Cullen, L., Egerton-Warburton, D. and Fatovich, D. M. (2018), Don't just do something, stand there! The value and art of deliberate clinical inertia. Emergency Medicine Australasia. doi:10.1111/1742-6723.12922
D-DIMER >500? NO PROBLEM! THEY STILL DON'T HAVE A PE...van der Hulle, TomFogteloo, Anne J et al. (2017). Simplified diagnostic management of suspected pulmonary embolism (the YEARS study): a prospective, multicentre, cohort study. The Lancet , Volume 390 , Issue 10091 , 289 - 297
ON FINDING THE COURAGE TO RESIST OVERDIAGNOSIS: Heath, I. Overdiagnosis - when good intentions meet vested interests - an essay. BMJ 2013;347:f6361 doi: 10.1136/bmj.f6361 (Published 25 October 2013)
IF YOU READ THE ABSTRACT YOU'D BE WRONG: The Impact of Clinical Decision Rules on Computed Tomography Use and Yield for Pulmonary Embolism: A Systematic Review and Meta-analysis. Wang, Ralph C. et al. Annals of Emergency Medicine , Volume 67 , Issue 6 , 693 - 701.e3
Sepsis references
Hydrocortisone, Ascorbic acid, thiamine
Hydrocortisone | ascorbic acid | thiamine therapy in sepsis Marik, Paul E. et al. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. Chest. 2017 Jun;151(6):1229-1238
Fludrocortisone and mortality Annane D, Renault A, Brun-Buisson C, Megarbane B, Quenot JP, Siami S, Cariou A, Forceville X, Schwebel C, Martin C, et al. Hydrocortisone plus fludrocortisone for adults with septic shock. N Engl J Med. 2018;378(9):809–18.
Hydrocortisone and vasopressor weaning Venkatesh B, Finfer S, Cohen J, Rajbhandari D, Arabi Y, Bellomo R, Billot L, Correa M, Glass P, Harward M, et al. Adjunctive glucocorticoid therapy in patients with septic shock. N Engl J Med. 2018;378(9):797–808
Vasopressors in sepsis
CATS - adrenaline vs noradrenaline for MAP >70mmHg in critically ill patients
SOAP-2 - dopamine vs noradrenaline for shock
VANISH - vasopressin vs noradrenaline for kidney disease in sepsis
VASST - vasopressin vs noradrenaline in septic shock
ATHOS-3 - angiotensin II in septic shock